Each industrial revolution has caused changes in most parts of the world in its own way. However, the latest revolution, the so-called Industry 4.0, with its depth and breadth, absolutely changed the thinking and functioning of organizations, including human resources in companies. The aim of the paper is to theoretically summarize the main findings about the changes and effects from new technologies according to Industry 4.0 requirements that have been recorded in the Labour Market and in the Human Resource Management. New technologies are bringing a new era, new business, new approaches to functioning, as well as new jobs that require new competencies and promising skills. The findings show that HR professionals play a key role in developing their competencies to create opportunities and mitigate the challenges that Industry 4.0 brings to HR. Study also state that several authors began to deal with the various influences of Industry 4.0 on Human Resources and agree that the impact of Industry 4.0 on HR is understudied than in other areas. However, it is necessary in the future to determine the more precise changes that companies have to make in field of HR.